Protein Details: Calcium-activated chloride channel regulator 4A

Protein ID

ICDB_Pro_1105

Protein Name

Calcium-activated chloride channel regulator 4A

Gene Name

Clca4a; Clca6

Organism

Mus musculus (Mouse)

Length

924 amino acids

AlphaFoldDB

AF-Q6Q473-F1-model_v4.pdb

Function

May be involved in mediating calcium-activated chloride conductance.

Sequence

MAFSRGPVFLLLLLYLLWGSDTSLIRLNENGYEDIIIAIDPAVPEDTTIIEHIKGMVTKASTYLFEATEKRFFFKNVSILIPESWKDSPQYRRPKQESYKHADIKVAPPTVEGRDEPYTRQFTQCEEKAEYIHFTPDFVLGRKQDEYGDSGKVLVHEWAHLRWGVFDEYNEDQPFYSASSKKIEATRCSTGITGTNRVYACQGGSCAMRRCRTNSTTKLYEKDCQFFPDKVQSEKASIMFMQSIDSVTEFCKKENHNREAPTLHNKKCNYRSTWEVISTSEDFNSSTPMETSPSPPFFSLLRISERIMCLVLDVSGSMTSYDRLNRMNQAAKYFLSQIIENRSWVGMVHFSSQATIVHELIQINSDIERNQLLQTLPTSANGGTSICSGIKAAFQVFKNGEYQTDGTEILLLSDGEDSTAKDCIDEVKDSGSIVHFIALGPLADLAVTNMSILTGGNHKLATDEAQNNGLIDAFGALASENADITQKSLQLESKGAILNNSLWLNDTVVIDSTLGRDTFFLVTWSKQAPAIYLRDPKGTQTTNFTMDSASKMAYLSIPGTAQVGVWTYNLEAKENSEILTITVTSRAANSSVPPITVNAKVNTDTNTFPSPMIVYAEVLQGYTPIIGARVTATIESNSGKTEELVLLDNGAGADAFKDDGVYSRFFTAYSVNGRYSLKVRADGGRNSARRSLRHPSSRAAYIPGWVVDGEIQGNPPRPETTEATQPVLENFSRTASGGAFVVSNVPSGPLPDLYPPNQITDLQATLDGEEISLTWTAPGDDYDVGRVQQYIIRTSKNIIELRDNFNNSPRVDTTNLTPKEANSEETFAFKPENITEENATYIFIAIESVDKSSLSSGPSNIAQVALFTPQAEPDPDESPSSSGVSVATIVLSVLGALVLVCIIVGTTICILKNKRSSSAAITKF

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 156; /ligand="Zn(2+)"; /ligand_note="catalytic"; BINDING 160; /ligand="Zn(2+)"; /ligand_note="catalytic"; BINDING 167; /ligand="Zn(2+)"; /ligand_note="catalytic";

Disease

Location

Expressed in the non-goblet intestinal cells. High levels in intestine and stomach; and lower levels in eye; liver and spleen. Increasing expression from the duodenum to the ilium; and decreasing expression to the colon. Increasing expression from the duodenum to the ilium; and decreasing expression to the colon. Increasing expression from the duodenum to the ilium; and decreasing expression to the colon. Isoform 2 is expressed in intestine and stomach but at lower levels than isoform 1

DOI ID

10.1074/jbc.m408354200; 10.1369/jhc.2008.950592